Description
Product Characteristics:
CTR9 is a component of the PAF (polymerase-associated factor) complex which interacts with histone-modifying enzymes and RNA polymerase II and plays a role in a number of transcription-related processes. Recent studies show that CTR9 can regulate IL-6-responsive gene transcription by influencing histone methylation.
Subcellular location: Nucleus
Synonyms: SH2BP1, TSBP, Ctr 9, Ctr9, Ctr9 Paf1/RNA polymerase II complex component, homolog, p150, RNA polymerase associated protein CTR9 homolog, SH2 binding phosphoprotein, SH2 domain binding protein 1 tetratricopeptide repeat containing, TPR containing SH2 binding phosphoprotein, Paf1/RNA polymerase II complex component homolog Ctr9, SH2 domain binding protein 1, CTR9_HUMAN.
Target Information: CTR9, parafibromin (CDC73\, MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]