Description
Product Characteristics:
TSC-36 is a secreted extracellular glycoprotein. The amino acid sequence of TSC-36 is similar to follistatin, an inhibitor of activin, as it contains a follistatin module. TSC-36 is a heparin-binding protein suggested to have a role in the negative regulation of cellular growth, as its expression is induced in response to TGF-b1. In addition, TSC-36 is not found in small cell lung cancer (SCLC) cells, a highly aggressive neoplasm, but is detected in some non-small cell lung cancer (NSCLC) cells, a moderately aggressive neoplasm. May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.
Subcellular location: Secreted
Synonyms: FSTL1, TSC-36, Follistatin like 1, Follistatin related protein, Follistatin-like protein 1, Follistatin-related protein 1, FRP, FSL1, FSTL1, FSTL1_HUMAN.
Target Information: This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]