Description
Product Characteristics:
SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Cbl interacting protein, Cbl interacting protein of 85 kDa, CD2 binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, Human Src family kinase binding protein 1, MIG 18, MIG18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3BP 1, Src family kinase binding protein 1, src related kinase binding protein 1, SH3K1_HUMAN.
Target Information: This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]