Description
Product Characteristics: Human Transferrin Receptor which is expressed on proliferating lymphoblasts, majority human tumour cell lines, normal peripheral blood monocytes. The CD71 antibody in routine is used along with the glycophorin A to develop a flow-cytometric approach to the evaluation of erythroid and myeloid dysplasia in patients with Myelodysplatic Syndromes (MDS). Another of the applications of the CD71 antibody, is the recount of retyculocites2, immature red corpuscles, without nucleus, that contain ribonucleic acid (RNA). peripheral blood, they delay approximately a day in losing their RNA and to be become erythrocytes. Its recount provides information on the production of erythrocytes.
Target Information: This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Mar 2010]