Description
Product Characteristics:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subcellular location: Cell membrane
Synonyms: APNH, NHE1, LIKNS, NHE-1, PPP1R143, Sodium/hydrogen exchanger 1, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, Solute carrier family 9 member 1, SLC9A1, APNH1
Target Information: This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]