Description
Product Characteristics: Ascc1 enhances NF-kappa-B, SRF and AP1 transactivation. Synonyms: Polyclonal Ascc1 antibody, Anti-Ascc1 antibody, activating signal cointegrator 1 complex subunit 1 antibody, Asc-1 antibody, CGI-18 antibody, MGC94577 antibody, Ascc1 antibody.
Target Information: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]