Description
Product Characteristics:
Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Apoptotic protein NDPP 1, Apoptotic protein NDPP1, CARD 8, CARD inhibitor of NF kappa B activating ligand, CARD inhibitor of NF kappaB activating ligand, CARD inhibitor of NF kappaB activating ligands, CARD-inhibitor of NF-kappa-B-activating ligand, CARD8, CARD8_HUMAN, CARDINAL, Caspase recruitment domain containing protein 8, Caspase recruitment domain family member 8, Caspase recruitment domain protein 8, Caspase recruitment domain-containing protein 8, DACAR, NDPP 1, NDPP1, TUCAN, Tumor up regulated CARD containing antagonist of CASP9, Tumor up regulated CARD containing antagonist of caspase 9, Tumor up-regulated CARD-containing antagonist of CASP9, Tumor upregulated CARD containing antagonist of CASP9.
Target Information: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]