Description
Product Characteristics:
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.
Subcellular location: Secreted, Extracellular matrix
Synonyms: ABP, Abp1, ABP1_HUMAN, Amiloride binding protein 1 amine oxidase copper containing, Amiloride binding protein 1, Amiloride binding protein, Amiloride sensitive amine oxidase, Amiloride-binding protein, Amiloride-sensitive amine oxidase [copper-containing], AOC1, DAO, DAO1, Diamine oxidase, Histaminase, KAO, Kidney amine oxidase.
Target Information: This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]