Description
Product Characteristics:
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
Subcellular location: Cell membrane
Synonyms: CD218a, IL18RA, IL1RRP, CDw218a, IL-1Rrp, Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, IL1 receptor-related protein, IL1R-rp, IL18R1
Target Information: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq, Jul 2008]