Description
Product Characteristics:
Get4 is a 327 amino acid cytoplasmic protein that exists as two alternatively spliced isoforms. Get4 forms a multiprotein complex, known as the BAT3 complex, with UBL4A, BAT3 and ARSA. The BAT3 complex plays a role in transporting tail-anchored membrane proteins to the endoplasmic reticulum membrane. The gene encoding Get4 maps to human chromosome 7p22.3. Human chromosome 7 houses over 1,000 genes, comprises nearly 5 % of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
Subcellular location: Cytoplasm
Synonyms: C7orf20, CGI 20, CGI20, Conserved edge expressed protein, Conserved edge protein, Conserved edge-expressed protein, GET 4, GET4, GET4_HUMAN, Golgi to ER traffic protein 4 homolog S. cerevisiae, Golgi to ER traffic protein 4 homolog, Transmembrane domain recognition complex 35 kDa subunit, Transmembrane domain recognition complex 35 kDa, TRC35, UPF0363 protein C7orf20, GET4_HUMAN.
Target Information: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region (By similarity)