Description
Product Characteristics:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. May have a growth inhibitory role. Ubiquitous, expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: N-myc downstream regulated gene 1, TDD5, 42 kDa, cap43, cmt4d, Dferentiation related gene1 protein, Drg 1, drg1, gc4, hmsnl, Human mRNA for RTP complete cds, N myc downstream regulated gene 1 protein, Ndr 1, NDRG 1, Nickel specic induction protein Cap43, Nmyc downstream regulated gene1, Protein NDRG1, Protein regulated by oxygen 1, Protein regulated by oxygen1, proxy1, reducin, Reducing agents and tunicamycin responsive protein, rit42, rtp, targ1, tdds, tunicamycin-responsive protein.
Target Information: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]