Description
Product Characteristics:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3.
Subcellular location: Cytoplasm
Synonyms: Apg 10, Apg-10, APG 10L, APG10 autophagy 10 like, APG10 like, APG10-like, APG10L, ATG 10, ATG10, ATG10 autophagy related 10 homolog S. cerevisiae, ATG10 autophagy related 10 homolog, ATG10_HUMAN, Autophagy related protein 10, Autophagy-related protein 10, Ubiquitin-like-conjugating enzyme ATG10
Target Information: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A\, MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]