Description
Product Characteristics:
Component of the vault ribonucleoprotein particle which is at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1. Widely expressed, the highest levels are in the kidney, also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.
Subcellular location: Cytoplasm, Nucleus
Synonyms: PARP related / IalphaI related H5 / proline rich, Vault poly ADP ribose polymerase, VPARP, 193 kDa vault protein, ADP ribosyltransferase NAD+ poly ADP ribose polymerase like 1, ADP ribosyltransferase like 1, ADPRT L1, ADPRTL 1, ADPRTL1, H5 proline rich, I alpha I related, KIAA0177, Minor vault p193 protein, p193 antibody PARP 4, PARP related, PARPL, PH 5P, PH5P, Poly ADP ribose polymerase 4, Poly ADP ribose polymerase family member 4, Poly ADP ribose synthetase, Poly ADP ribosyl transferase like 1, Poly ADP ribose polymerase 4, Poly ADP ribose polymerase family member 4, Vault 3, Vault, Vault poly ADP ribose polymerase, Vault protein 193 kDa, Vault3, PARP4_HUMAN.
Target Information: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]