Description
Product Characteristics:
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.Tissue specificity, Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.Sequence similarities, Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: 17-beta-HSD 6, 17-beta-HSD6, 17-beta-hydroxysteroid dehydrogenase type 6, 3 hydroxysteroid epimerase, 3alpha >beta hydroxysteroid epimerase, 3alpha >beta hydroxysteroid epimerasel, 3-alpha->beta-HSE, 3-alpha->beta-hydroxysteroid epimerase, H17B6_HUMAN, HSD17B6, HSE, Hydroxysteroid 17 beta dehydrogenase 6, Hydroxysteroid 17 beta dehydrogenase 6 homolog mouse, Hydroxysteroid 17 beta dehydrogenase 6, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase, Oxidative 3 alpha hydroxysteroid dehydrogenase, Oxidative 3-alpha hydroxysteroid dehydrogenase, Oxidoreductase, Retinol dehydrogenase, RODH, SDR9C6,Short chain dehydrogenase/reductase family 9C, member 6.
Target Information: The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist. [provided by RefSeq, Jul 2008]