Description
Product Characteristics:
NSP type 5 alpha 3 alpha is a novel structure protein belonging to the cytospin-A family, that may play a role in nuclear function during cell division. It is also highly expressed in certain tumor cell lines, suggesting that it may serve as a good tumor marker. It was was cloned as part of a chromosomal translocation involving PDGFRB in a case of juvenile myelomonocytic leukemia.
Subcellular location: Nucleus
Synonyms: Cytokinesis and spindle organization B, Cytospin B, FLJ36955, HCMOGT 1, NSP, NSP5, Nuclear structure protein 5, SPECC1, Spectrin domain with coiled coils 1, Sperm antigen HCMOGT 1, Sperm antigen with calponin homology and coiled coil domains 1, Structure protein NSP5a3a, Structure protein NSP5a3b, Structure protein NSP5b3a, Structure protein NSP5b3b, CYTSB_HUMAN.
Target Information: The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]