Description
Product Characteristics:
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar2009].
Subcellular location: Cytoplasm
Synonyms: HSPK 36, HSPK36, HSPK-36, NEK3, NEK 3, NEK-3, NEK3_HUMAN, Never in mitosis A-related kinase 3, NIMA never in mitosis gene a related kinase 3, NimA related protein kinase 3, NimA-related protein kinase 3, Serine/threonine protein kinase Nek3, Serine/threonine-protein kinase Nek3.
Target Information: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]