Description
Product Characteristics:
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
Subcellular location: Secreted, Cell membrane
Synonyms: MCK10 phospho Y513, p-MCK10 phospho Y513, CAK, CD167a, DDR1CD 167, CD167, Cell adhesion kinase, DDR 1, DDR, DDR1, Discoidin domain receptor, Discoidin receptor tyrosine kinase isoform a, EDDR 1, Epithelial discoidin domain receptor 1, Epithelial specic receptor kinase, Mammarian carcinoma kinase 10, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, PTK 3, PTK 3A protein tyrosine kinase 3A, Receptor tyrosine kinase NEP, RTK 6, TRK E, Tyrosine kinase receptor E, DDR1_HUMAN.
Target Information: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]