Description
Product Characteristics:
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, PRKACB
Target Information: active catalytic subunit of protein kinase A\, phosphorylates and activates transcription factors in response to elevated levels of cAMP\, mediates phosphorylation and regulation of enzyme substrates involved in intermediary metabolism [RGD, Feb 2006]