Description
Product Characteristics:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Par 6 partitioning defective 6 C elegans homolog alpha, Par 6 partitioning defective 6 homolog alpha C elegans, PAR 6A, PAR-6 alpha, PAR-6, PAR-6A, PAR6, PAR6A_HUMAN, PAR6alpha, PAR6C, PARD6A, Partitioning defective 6 homolog alpha, Tax interacting protein 40, Tax interaction protein 40, TAX40, TIP 40, TIP-40, TIP40.
Target Information: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]