Description
Product Characteristics:
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Subcellular location: Cytoplasm
Synonyms: Transmembrane prolyl 4-hydroxylase, Proline hydrolase 4, proline 4-hydroxylase, P4htm, hypoxia-inducible factor prolyl 4-hydroxylase, P4H-TM, H-prolyl hydroxylase PH-4, P4HTM_HUMAN, Hypoxia-inducible factor prolyl hydroxylase 4, H-PH4, H-prolyl hydroxylase 4, HPH-4, transmembrane prolyl 4-hydroxylase isoform a, P4HTM, EGLN4, HPH4, P4H-TM, PH-4, PH4, PHD4, P4H with transmembrane domain, Prolyl hydroxlase domain-containing 4, hypoxia inducible factor prolyl 4 hydroxylase, H-prolyl hydroxylase 4.
Target Information: The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]