Description
Product Characteristics:
The synucleins, including Alpha-synuclein (also designated NACP for nonamyloid component precursor),Beta-synuclein (also designated PNP 14 for neuroprotein 14)and Gamma-synuclein (also designated persyn or BCSG1 for breast cancer-specific gene 1)are presynaptic protein abundant in neurons. Alpha-synuclein, a component of Alzheimer?s disease amyloid plaques, is localized to neuronal cell bodies and synapses. Coordinate expression of Alpha-synucleinand Beta-synuclein may be important during hematopoetic cell differentiation. In patients with Parkinson?s disease, a mutant form of Alpha-synuclein has been found and Gamma-synuclein is associated with axonal pathology.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: SNCAphospho S129, alpha Synuclein phospho S129,alpha-Synuclein Ser129, Synuclein alphaSer129, Alpha synuclein, Alpha-Synuclein, Alpha-synuclein, isoform NACP140, alpha SYN, MGC105443, MGC110988, MGC127560, MGC64356, NACP, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid, precursor of, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK 1, PARK 4, PARK1, PARK4, Parkinson disease autosomal dominant, Lewy body 4, Parkinson disease familial 1, PD 1, PD1, Syn, SNCA, Snca synuclein, alpha non A4 component of amyloid precursor, SYUA_HUMAN, Synuclein alpha, Synuclein, alpha non A4 component of amyloid precursor,
Target Information: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]