Description
Product Characteristics:
SMC5/6 complex is recruited to nuclease induced double strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. The human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells.
Subcellular location: Cytoplasm, Nucleus
Synonyms: SMC6L1, SMC 6, SMC6, SMC6 protein, SMC6 structural maintenance of chromosomes 6 like 1, Structural maintenance of chromosomes 6, Structural maintenance of chromosomes 6 like 1, Structural maintenance of chromosomes protein 6.
Target Information: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity)