Description
Product Characteristics:
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: DAP kinase related apoptosis inducing protein, DAP kinase related apoptosis inducing protein kinase 2, Death associated protein kinase related 2, DRAK 2, Serine/threonine kinase 17b apoptosis inducing, Serine/threonine kinase 17b, Serine/threonine protein kinase 17B, STK17B, ST17B_HUMAN.
Target Information: over-expression causes apoptosis-like cell death which is dependent on the kinase activity [RGD, Feb 2006]