Description
Product Characteristics:
Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Subcellular location: Secreted, Extracellular matrix
Synonyms: 9K, M2BP, gp9, CyCAP, BTBD17B, MAC-2-BP, TANGO1B, Galectin-3-binding protein, Basement membrane autoantigen p15, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Tumor-associated antigen 9K, LGALS3BP
Target Information: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]