Description
Product Characteristics:
Fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin ?s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.
Subcellular location: Cytoplasm
Synonyms: 55 kDa actin bundling protein, 55 kDa actin-bundling protein, Actin bundling protein, FAN 1, Fscin1, FAN1, Fascin 1, Fascin, Fascin homolog 1 actin bundling protein Strongylocentrotus purpuratus, Fascin homolog 1, Fascin1, FLJ38511, FSCN 1, FSCN1, FSCN1_HUMAN, HSN, p55, Singed Drosophila like sea urchin fascin homolog like, Singed drosophila homolog like, Singed like fascin homolog sea urchin Drosophila, Singed like fascin homolog sea urchin, Singed like protein, Singed-like protein, SNL, Strongylocentrotus purpuratus.
Target Information: This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]