Description
Product Characteristics:
Testis and very low level in placenta and in some uterus samples. Observed in 25-50 % of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers.
Subcellular location: Cytoplasm
Synonyms: CT2, ESO2, CAMEL, CT6.2, CT6.2a, CT6.2b, LAGE-1, LAGE2B, Cancer/testis antigen 2, Autoimmunogenic cancer/testis antigen NY-ESO-2, Cancer/testis antigen 6.2, L antigen family member 1, CTAG2, LAGE1
Target Information: This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO\\/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID 10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]