Description
Product Characteristics:
ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression.
Subcellular location: Nucleus
Synonyms: zinc finger protein 217, ZABC 1, ZABC1, ZN 217, ZN217, ZNF 217, 4933431C08Rik, AW987152, Gm562, Zfp217, ZN217_HUMAN.
Target Information: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'