Description
Product Characteristics:
Contactin 2 is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunogobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
Subcellular location: Cell membrane
Synonyms: Axonal glycoprotein TAG 1, Axonal glycoprotein TAG-1, Axonal glycoprotein TAG1, Axonin 1, Axonin-1, Axonin1, AXT, CNTN 2, Cntn2, CNTN2_HUMAN, contactin 2 axonal, Contactin 2, Contactin-2, Contactin2, DKFZp781D102, MGC157722, TAG 1, TAG 564, TAG564, TAX 1, TAX, TAX-1, TAX1, Transient axonal glycoprotein 1, Transiently expressed axonal glycoprotein.
Target Information: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008]