Description
Product Characteristics:
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: cAMP specic 3',5' cyclic phosphodiesterase 4D, DKFZp686M11213, FLJ97311, cAMP specic 3' 5' cyclic phosphodiesterase 4D, cAMP specic phosphodiesterase 4D, cAMP specic phosphodiesterase PDE4D, cAMP specic phosphodiesterase PDE4D6, cyclic AMP phosphodiesterase, DPDE 3, DPDE3, Dunce like phosphodiesterase E3, HSPDE4D, PDE 43, PDE43, PDE4DN2, Phosphodiesterase 4D cAMP specic dunce Drosophila homolog phosphodiesterase E3, Phosphodiesterase 4D cAMP specic phosphodiesterase E3 dunce homolog Drosophila, Phosphodiesterase 4D cAMP specic, Phosphodiesterase 4D, cAMP specic dunce, Phosphodiesterase E3 dunce homolog Drosophila, STRK 1, STRK1.
Target Information: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]