Description
Product Characteristics:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Subcellular location: Cytoplasm, Nucleus
Synonyms: BOR, BOREA_HUMAN, Borealin, CDCA8, Cell division cycle associated 8, Cell division cycle-associated protein 8, Dasra B, Dasra-B, DasraB, FLJ10468, FLJ12042, hDasra-B, MESRGP, OTTHUMP00000004514, Pluripotent embryonic stem cell-related gene 3 protein.
Target Information: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]