Description
Product Characteristics:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Subcellular location: Nucleus
Synonyms: Thyroid hormone receptor, Thyroid hormone receptor alpha, Thyroid hormone receptor beta, Thyroid hormone receptor alpha 1, Thyroid hormone receptor alpha 2, Thyroid hormone receptor beta 1, Thyroid hormone receptor beta 2.
Target Information: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]