Description
Product Characteristics:
This gene encodes a proline rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53 mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.
Subcellular location: Cytoplasm
Synonyms: DDA3, Dferential display and activated by p53, FP3214, p53-regulated DDA3, Proline/serine-rich coiled-coil 1, proline/serine-rich coiled-coil protein 1, PSRC1_HUMAN.
Target Information: This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2009]