Description
Product Characteristics:
C17orf71 belongs to the UPF0487 family. There are 3 isoforms produced by alternative splicing.Positive control,Human Anaplastic Thyroid Carcinoma, Human Breast Carcinoma.
Subcellular location: Cytoplasm
Synonyms: ABC 2, ABC2, ABC-2, Amplied in breast cancer gene 2 protein, Chromosome 17 open reading, chromosome 17 open reading frame 71, Protein smg 8 homolog, protein SMG8, SMG8, SMG8 protein, SMG8_HUMAN.
Target Information: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]