Description
Product Characteristics:
SLC25A11 catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Mitochondrial 2 oxoglutarate/malate carrier protein, OGC, OGCP, SLC20A4, Solute carrier family 20 oxoglutarate carrier member 4, Solute carrier family 20 member 4, Solute carrier family 25 mitochondrial carrier oxoglutarate carrier member 11, Solute carrier family 25 member 11.
Target Information: The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]