Description
Product Characteristics:
This protein is expressed in colon, lung and liver. Defects in PDGFRL are associated with colorectal cancer.
Subcellular location: Secreted
Synonyms: PDGF receptor beta like tumor suppressor, PGFRL_HUMAN, PDGFR-like protein, PDGRL, PRLTS.
Target Information: This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]