Description
Product Characteristics:
Natural killer (NK) cells express multiple C-type (calcium-dependent) lectin-like receptors, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC1B (also known as CLEC-2) is a C-type lectin-like receptor expressed in myeloid cells and NK cells.
Subcellular location: Cell membrane
Synonyms: CLEC2, CLEC2B, PRO1384, QDED721, 1810061I13Rik, C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2, CLEC1B, UNQ721/PRO1384
Target Information: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\, MIM 602894) and NKG2D (KLRC4\, MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]