Description
Product Characteristics:
Not known, though may play a role in tumor transformation or aspects of tumor progression.Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Cancer/testis antigen 1.12, Cancer/testis antigen family 1 member 12, CT1.12, MAGAC_HUMAN, MAGE 12 antigen, MAGE-12 antigen, MAGE12, MAGE12 antigen, MAGE12F, MAGE12F antigen, MAGEA12, Melanoma antigen family A 12, Melanoma associated antigen 12, Melanoma-associated antigen 12.
Target Information: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]