Description
Product Characteristics:
ABIN-3 is a member of the A20-binding inhibitor of NF-kappaB activation (ABIN) protein family. Similar to the previously characterized human ABINs (ABIN-1 and ABIN-2), ABIN-3 can bind to A20 and inhibit NF-kappaB activation. In contrast, mouse ABIN-3 is incapable of inhibiting NF-kappaB activation by proinflammatory stimuli because the protein lacks a complete ABIN homology domain, which is required for the funcitonal activity of human ABIN-3.
Subcellular location: Cytoplasm
Synonyms: Listeria induced, A20-binding inhibitor of NF-kappa-B activation 3, ABIN-3, ABIN-3 beta, FLJ21162, LIND, Listeria induced gene protein, TNFAIP3 interacting protein 3, TNFAIP3-interacting protein 3 beta, TNIP3, TNIP3 beta, TNIP3_HUMAN.
Target Information: Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding