Description
Product Characteristics:
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Cytotoxic granule associated RNA binding protein 1, Cytotoxic granule associated RNA binding protein, mTIA-1, Nucleolysin TIA 1 isoform p40, Nucleolysin TIA-1 isoform p40, Nucleolysin TIA1 isoform p40, p40 TIA 1, p40-TIA-1, RNA binding protein TIA 1, RNA binding protein TIA1, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA 1, TIA 1 cytotoxic granule associated RNA binding protein, TIA-1, TIA1, TIA1 cytotoxic granule associated RNA binding protein, TIA1 cytotoxic granule associated RNA binding protein like 1, TIA1 protein, TIA1_HUMAN, TIAL1, TIAR.
Target Information: The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]