Description
Product Characteristics:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Prp9 1, ATP dependent helicase CHD3, ATP-dependent helicase Chd3, CHD-3, Chd3, CHD3_HUMAN, Chd7, Chromodomain-helicase-DNA-binding protein 3, hZFH, MGC40857, Mi 2 autoantigen 240 kDa protein, Mi 2a, Mi-2 autoantigen 240 kDa protein, Mi2 ALPHA, Mi2-alpha, Prp7, ZFH, Zinc finger helicase.
Target Information: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]