Description
Product Characteristics:
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Subcellular location: Cytoplasm, Nucleus
Synonyms: A1S9, A1S9 protein, A1S9T and BN75 temperature sensitivity complementing, A1S9T, A1ST, GXP 1, GXP1, MGC4781, Protein A1S9, Uba1, UBA1_HUMAN, UBE 1, UBE 1X, UBE1, UBE1X, Ubiquitin activating enzyme E1, Ubiquitin-activating enzyme E1, Ubiquitin-like modier-activating enzyme 1.
Target Information: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]