Description
Product Characteristics:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Subcellular location: Cytoplasm
Synonyms: Xlkd1, Lyve-1, Crsbp-1, 1212G8Rik, Lymphatic vessel endothelial hyaluronic acid receptor 1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, Lyve1, Crsbp1
Target Information: This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]