Description
Product Characteristics: Anti-CD31 TP1/15, was included in the Fifth International Workshops on Human Leucocyte Differentiation Antigens. Human CD31 is an adhesion molecule expressed on platelets, endothelial cells, leukocytes and their bone marrow precursors. CD31 plays a role in homophilic adhesion and heterophilic transendothelial migration. Antibody TP1/15 reacts with domain 1 of CD31 and blocks homophilic interaction and heterophilic transendothelial migration. Expressed diffusely by monocytes, neutrophils, and NK cells. Expressed on subsets of T cells, not on circulating B cells.
Target Information: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]