Description
Product Characteristics: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Target Information: homolog of Drosophila slit\, may play a role in protein-protein interactions during midline formation in the central nervous system\, specifically expressed in fetal and adult forebrain neurons [RGD, Feb 2006]