Description
Product Characteristics:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Kelch like ECT2 interacting protein, Kelch like protein 20, Kelch like protein X, Kelch mot containing protein, Kelch-like ECT2-interacting protein, Kelch-like protein 20, Kelch-like protein X, KHLHX, KLEIP, KLH20_HUMAN, KLHL20, KLHLX, RP3-383J4.3.
Target Information: The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]