Description
Product Characteristics:
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
Subcellular location: Secreted, Cell membrane
Synonyms: MDCL, MDC-L, eMDCII, ADAM 28, eMDC II, Disintegrin and metalloproteinase domain-containing protein 28, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, ADAM28, ADAM23
Target Information: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform. [provided by RefSeq, Jul 2008]