Description
Product Characteristics:
Has both helicasee and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity, This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Subcellular location: Cytoplasm, Nucleus
Synonyms: DNA-binding protein/plasminogen activator inhibitor 1 regulator, Helicase like transcription factor, Helicase-like transcription factor, HIP116, HIP116A, HLTF 1, HLTF, HLTF_HUMAN, HLTF1, p113, RING finger protein 80, RNF80, SMARC A3, SMARCA 3, SMARCA3, SNF2-like 3, SNF2L3, Sucrose nonfermenting protein 2 like 3, Sucrose nonfermenting protein 2-like 3, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, ZBU 1, ZBU1.
Target Information: This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]