Description
Product Characteristics:
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Subcellular location: Nucleus
Synonyms: LBP 1a, Cp2b, DKFZp686L1745, LBP 1a, LBP 1B, LBP1, LBP1A, LBP1B, NF2d9, Upstream binding protein 1, Transcription factor LBP-1, UBIP1_HUMAN.
Target Information: Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha- globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299\, binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity)