Description
Product Characteristics:
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Maternal inhibition of dferentiation, SECC 8, SSEC 8, CCDB1_HUMAN, CCNDBP 1, Ccndbp1, Cyclin D type binding protein 1, Cyclin-D1-binding protein 1, D type cyclin interacting protein 1, DIP 1, DIP1, GCIP, Grap 2 and cyclin D interacting protein, Grap 2 cyclin D interacting protein GCIP, Grap 2 cyclin interacting protein, Grap2 and cyclin D interacting protein, Grap2 and cyclin-D-interacting protein, Grap2 cyclin D interacting protein GCIP, Grap2 cyclin interacting protein, HHM protein, Human homolog of Maid, MAID, MAID protein, Stage specic embryonic cDNA 8.
Target Information: This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]