Description
Product Characteristics:
CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: Sip2-28, Cibkip, Kip, Prkdcip, CIB1_HUMAN, Calcium and integrin-binding protein 1,CIB,Calcium- and integrin-binding protein,CIBP,Calmyrin,DNA-PKcs-interacting protein,Kinase-interacting protein,KIP,SNK-interacting protein 2-28,SIP2-28.
Target Information: This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]